Exosome-mediated Transfer of lncRNA in Liver Associated Diseases; Uncovered Truths
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Date
2024-11-20
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Cell Biochemistry and Biophysics https://doi.org/10.1007/s12013-024-01617-x
Abstract
Abstract
Exosomes are extracellular vesicles with a diameter ranging from 40 to 160 nm. They are produced by hepatocytes,
cholangiocytes, hepatic stellate cells (HSCs), liver sinusoidal endothelial cells (LSECs), and Kupffer cells in liver tissue. The
secretion of exosomes might vary in quantity and composition in reaction to multiple triggers and various stages of disease.
They transport various payloads, such as proteins, DNAs, and RNAs, and enable cell interaction to regulate myriad
physiological and pathological processes in liver tissue. Long non-coding RNAs (lncRNAs) are a crucial component of
exosomes with an excellent capability to regulate multiple cellular activities such as differentiation, development,
metabolism, proliferation, apoptosis, and activation. With the advancements in transcriptomic and genomic study methods
and database management technology, the functions and mechanisms of exosomal lncRNAs in liver diseases have been
well-studied. This article delves into the detailed role of exosomal lncRNAs in liver disease onset and progression, ranging
from hepatocellular carcinoma (HCC) to liver fibrosis drug-induced liver damage (DILI) and steatotic liver diseases.
Description
Description
Exosomes are small extracellular vesicles secreted by various liver cells, including hepatocytes, cholangiocytes, hepatic stellate cells (HSCs), liver sinusoidal endothelial cells (LSECs), and Kupffer cells. Their composition and quantity can change in response to different stimuli and disease conditions. These vesicles play a crucial role in intercellular communication by transporting biomolecules such as proteins, DNAs, and RNAs, including long non-coding RNAs (lncRNAs). Exosomal lncRNAs are key regulators of cellular functions like differentiation, proliferation, metabolism, and apoptosis. Advances in transcriptomics and genomics have enhanced the understanding of their role in liver diseases. This article explores the impact of exosomal lncRNAs on liver disease progression, including hepatocellular carcinoma (HCC), liver fibrosis, drug-induced liver injury (DILI), and steatotic liver diseases.
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Citation
Saleh, R. O., Hamad, H. A., Najim, M. A., Menon, S. V., Kaur, M., Sivaprasad, G. V., ... & Mustafa, Y. F. (2024). Exosome-mediated Transfer of lncRNA in Liver Associated Diseases; Uncovered Truths. Cell Biochemistry and Biophysics, 1-17.